Balance between NF-kB p100 and p52 Regulates T Cell Costimulation Dependence
نویسندگان
چکیده
منابع مشابه
Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.
c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress noncanonical NF-κB activation. We have created mice that bear a mutation in c-IAP2 that inactivates its E3 activity and interferes, in a dominant-negative fashion, with c-IAP1 E3 activity (c-IAP2(H570A)). The immune response of these animals was explored by infecting them with the Th1-inducing parasite Toxoplasma gondii. Surpris...
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